What is the pathophysiological reason for the development of renal calculi and associated treatment considerations to rid renal stones and prevent future development of others?

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A patient presents with flank pain. You suspect renal calculi. What is the pathophysiological reason for the development of renal calculi and associated treatment considerations to rid renal stones and prevent future development of others?
Explain the common conditions associated with proteinuria and hematuria. Discuss the rationale for potential complications.

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