STATISTICS AND DATA MANAGEMENT: ASSIGNMENT

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QUESTION

Beigel JH et al.  Remdesivir for the treatment of Covid-19 — Final Report.  N Engl J Med 2020; 383: 1813-26.

1. Describe the paper, its context, and comment on the value of the research, focusing on trial design, statistical techniques used to minimize bias, statistical methodology and approaches used to ensure correctness of inferences. The study findings including the key results should be discussed.  (25%).

2. Give a critique of the methodological steps used by the researchers for the study. Take into account the review questions from the Critical Assessment Skills Programme (CASP) http://www.casp-uk.net/casp-tools-checklists, plus other issues of relevance.  Discuss specifically any methodological limitations, and how these limitations impact on the conclusions of the study (40%). Indicate, where relevant, how these limitations could have been better managed (10%).

3. What original clinical study would you conduct to further investigate the author’s findings, or some of the findings identified?  Describe the study objectives, trial design, sample size, statistical methodology, the data collection and data management of your study (25%).

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