Skip to content
Home » NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    What’s Happening This Module?

    This course is composed of eight (8) separate modules. Each module consists of an overarching topic and each week within the module includes specific subtopics for learning. As you work through each module, you will draw upon the knowledge you gain by completing various Knowledge Checks and Case Study Assignments.

    Module 1: Foundational Concepts of Cellular Pathophysiology is a 2-week module, Weeks 1 and 2 of the course. In this module, you will examine fundamental concepts of cellular processes and the alterations that lead to various diseases. You will evaluate the genetic environment and its impact on these diseases. You will also evaluate the impact of patient characteristics, including racial and ethnic variables, on physiological functioning.

    What do I have to do?  When do I have to do it?    
    Review your Learning Resources Days 1–7, Weeks 1 and 2
    Discussion: Alterations in Cellular Processes Post by Day 3 of Week 1 and respond to your colleagues by Day 6 of Week 1.
    Module 1 Assignment: Case Study Analysis You are encouraged to work on your Module 1 Assignment throughout the module. However, this Assignment is not due until Day 7 of Week 2.

     

    Week 1: Cellular Processes and the Genetic Environment

    One of the more common biology analogies refers to cells as the “building blocks” of life. This rightfully places an emphasis on understanding cells, cellular behavior, and the impact of the environment in which they function.

    Such an understanding helps explain how healthy cell activity contributes to good health. Just as importantly, it helps explain how breakdowns in cellular behavior and alterations to cells lead to health issues.

    This week, you examine cellular processes that are subject to alterations that can lead to disease. You evaluate the genetic environments within which these processes exist as well as the impact these environments have on disease.

    Learning Objectives

    Students will:

    Evaluate cellular processes and alterations within cellular processes
    Evaluate the impact of the genetic environment on disease

    Learning Resources

    Required Readings (click to expand/reduce)

    McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

    Chapter 1: Cellular Biology; Summary Review
    Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents (pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review
    Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases
    Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review
    Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review
    Chapter 7: Innate Immunity: Inflammation and Wound Healing
    Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review
    Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review
    Chapter 10: Infection (pp. 289–303; stop at Infectious parasites and protozoans); (start at HIV); Summary Review
    Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review
    Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review
    Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review

    Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/

    Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls

    Required Media (click to expand/reduce)

    Module 1 Overview with Dr. Tara Harris 

    Dr. Tara Harris reviews the structure of Module 1 as well as the expectations for the module. Consider how you will manage your time as you review your media and Learning Resources throughout the module to prepare for your Discussion and Assignment. (4m)

    Immunity and Inflammation

    Khan Academy (2010, February 24). Inflammatory response | Human anatomy and physiology | Health & medicine [Video file]. Retrieved from https://www.youtube.com/watch?v=FXSuEIMrPQk  

    Note: The approximate length of the media program is 14 minutes.

    Soo, P. (2018, July 28). Pathophysiology Ch 10 alterations in immune function [Video file]. Retrieved from https://www.youtube.com/watch?v=Jz0wx1-jTds   

    Note: The approximate length of the media program is 37 minutes.

    Acid-Base Balance #1

    MedCram. (2012, April 28). Medical acid base balance, disorders & ABGs explained clearly [Video file]. Retrieved from https://www.youtube.com/watch?v=4wMEMhvrQxE 

    Note: The approximate length of the media program is 13 minutes.

    Acid-Base Balance #2

    MedCram. (2012, April 29). Medical acid base balance, disorders & ABGs explained clearly | 2 of 8 [Video file]. Retrieved from https://www.youtube.com/watch?v=GmEeKVTpOKI  

    Note: The approximate length of the media program is 15 minutes.

    Hyponatremia

    MedCram. (2017, December 23). Hyponatremia explained clearly (remastered) – Electrolyte imbalances [Video file]. Retrieved from https://www.youtube.com/watch?v=bLajK5Vy55M 

    Note: The approximate length of the media program is 15 minutes.

     

    Online Media from Pathophysiology: The Biologic Basis for Disease in Adults and Children

    In addition to this week’s media, it is highly recommended that you access and view the resources included with the course text, Pathophysiology: The Biologic Basis for Disease in Adults and Children. Focus on the videos and animations in Chapters 3, 7, and 8 that relate to alterations in immunity, hyponatremia, and acid/base balance. NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    Note: To access the online resources included with the text, you need to complete the FREE online registration that is located at https://evolve.elsevier.com/cs/store?role=student

    To Register to View the Content

    Go to https://evolve.elsevier.com/cs/store?role=student
    Enter the name of the textbook, Pathophysiology: The Biologic Basis for Disease in Adults and Children, or ISBN 9780323654395 (name of text without the edition number) in the Search textbox.
    Complete the registration process.
    ORDER NOW FOR CUSTOMIZED, INSTRUCTION-COMPLIANT PAPER

    To View the Content for This Text

    Go to https://evolve.elsevier.com/
    Click on Student Site.
    Type in your username and password.
    Click on the Login button.
    Click on the plus sign icon for Resources on the left side of the screen.
    Click on the name of the textbook for this course.
    Expand the menu on the left to locate all the chapters.
    Navigate to the desired content (checklists, videos, animations, etc.).

    Note: Clicking on the URLs in the APA citations for the Resources from the textbook will not link directly to the desired online content. Use the online menu to navigate to the desired content.

    Discussion: Alterations in Cellular Processes

    Photo Credit: Getty Images

    At its core, pathology is the study of disease. Diseases occur for many reasons. But some, such as cystic fibrosis and Parkinson’s Disease, occur because of alterations that prevent cells from functioning normally.

    Understanding of signals and symptoms of alterations in cellular processes is a critical step in diagnosis and treatment of many diseases. For the Advanced Practice Registered Nurse (APRN), this understanding can also help educate patients and guide them through their treatment plans.

    For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts.

    To prepare:

    By Day 1 of this week, you will be assigned to a specific scenario for this Discussion. Please see the “Course Announcements” section of the classroom for your assignment from your Instructor.

    By Day 3 of Week 1

    Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:

    The role genetics plays in the disease.
    Why the patient is presenting with the specific symptoms described.
    The physiologic response to the stimulus presented in the scenario and why you think this response occurred.
    The cells that are involved in this process.
    How another characteristic (e.g., gender, genetics) would change your response.

    Read a selection of your colleagues’ responses.

    By Day 6 of Week 1

    Respond to at least two of your colleagues on 2 different days and respectfully agree or disagree with your colleague’s assessment and explain your reasoning. In your explanation, include why their explanations make physiological sense or why they do not

    Note: For this Discussion, you are required to complete your initial post before you will be able to view and respond to your colleagues’ postings. Begin by clicking on the “Post to Discussion Question” link and then select “Create Thread” to complete your initial post. Remember, once you click on Submit, you cannot delete or edit your own posts, and you cannot post anonymously. Please check your post carefully before clicking on Submit!

    Submission and Grading Information

    Grading Criteria

    To access your rubric:

    Week 1 Discussion Rubric

    Post by Day 3 of Week 1 and Respond by Day 6 of Week 1

    To Participate in this Discussion:

    Week 1 Discussion

    What’s Coming Up in Week 2?

    Photo Credit: [BrianAJackson]/[iStock / Getty Images Plus]/Getty Images

    Next week, you will examine alterations in the immune system and the resultant disease processes. You will also consider patient characteristics, including racial and ethnic variables, that may impact altered physiology.

    Next Week

     

    Week 2: Altered Physiology

    With a place squarely in the spotlight for patients diagnosed with all manner of disease, APRNs must demonstrate not only support and compassion, but expertise to guide patients’ understanding of diagnoses and treatment plans.

    This expertise goes beyond an understanding of disease and sciences, such as cellular pathophysiology. APRNs must become experts in their patients, understanding their medical backgrounds, pertinent characteristics, and other variables that can be factors in their diagnoses and treatments. NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    This week, you examine alterations in the immune system and the resultant disease processes. You consider patient characteristics, including racial and ethnic variables, and the impact they have on altered physiology.

    Learning Objectives

    Students will:

    Evaluate cellular processes and alterations within cellular processes
    Analyze alterations in the immune system that result in disease processes
    Identify racial/ethnic variables that may impact physiological functioning
    Evaluate the impact of patient characteristics on disorders and altered physiology

    Learning Resources

    Required Readings (click to expand/reduce)

    McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

    Chapter 1: Cellular Biology; Summary Review
    Chapter 2: Altered Cellular and Tissue Biology: Environmental Agents(pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review
    Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases,
    Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review
    Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review
    Chapter 7: Innate Immunity: Inflammation and Wound Healing
    Chapter 8: Adaptive Immunity (stop at Generation of clonal diversity); Summary Review
    Chapter 9: Alterations in Immunity and Inflammation (stop at Deficiencies in immunity); Summary Review
    Chapter 10: Infection (stop at Infectious parasites and protozoans); (start at HIV); Summary Review
    Chapter 11: Stress and Disease (stop at Stress, illness & coping); Summary Review
    Chapter 12: Cancer Biology (stop at Resistance to destruction); Summary Review
    Chapter 13: Cancer Epidemiology (stop at Environmental-Lifestyle factors); Summary Review

    Note: You previously read these chapters in Week 1 and you are encouraged to review once again for this week.

    Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/

    ​Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls.
    Note: This article was presented in the Week 1 resources. If you read it previously you are encouraged to review it this week.

    Required Media (click to expand/reduce)

    Immunity and Inflammation

    Khan Academy (2010, February 24). Inflammatory response | Human anatomy and physiology  | Health & medicine [Video file]. Retrieved from https://www.youtube.com/watch?v=FXSuEIMrPQk  

    Note: The approximate length of the media program is 14 minutes.

    Soo, P. (2018, July 28). Pathophysiology Ch 10 alterations in immune function [Video file]. Retrieved from https://www.youtube.com/watch?v=Jz0wx1-jTds   

    Note: The approximate length of the media program is 37 minutes.

    Acid-Base Balance #1

    MedCram. (2012, April 28). Medical acid base balance, disorders & ABGs explained clearly [Video file]. Retrieved from https://www.youtube.com/watch?v=4wMEMhvrQxE

    Note: The approximate length of the media program is 13 minutes.

    Acid-Base Balance #2

    MedCram. (2012, April 29). Medical acid base balance, disorders & ABGs explained clearly | 2 of 8 [Video file]. Retrieved from https://www.youtube.com/watch?v=GmEeKVTpOKI  

    Note: The approximate length of the media program is 15 minutes.

    Hyponatremia

    MedCram. (2017, December 23). Hyponatremia explained clearly [LK1] (remastered) – Electrolyte imbalances [Video file]. Retrieved from https://www.youtube.com/watch?v=bLajK5Vy55M

    Note: The approximate length of the media program is 15 minutes.

     

    Online Media from Pathophysiology: The Biologic Basis for Disease in Adults and Children

    In addition to this week’s media, it is highly recommended that you access and view the resources included with the course text, Pathophysiology: The Biologic Basis for Disease in Adults and Children. Focus on the videos and animations in Chapters 3, 7, and 8 that relate to alterations in immunity, hyponatremia, and acid/base balance.

    Note: To access the online resources included with the text, you need to complete the FREE online registration that is located at https://evolve.elsevier.com/cs/store?role=student

    To Register to View the Content

    Go to https://evolve.elsevier.com/cs/store?role=student
    Enter the name of the textbook, Pathophysiology: The Biologic Basis for Disease in Adults and Children, or ISBN 9780323654395 (name of text without the edition number) in the Search textbox.
    Complete the registration process.

    To View the Content for This Text

    Go to https://evolve.elsevier.com/
    Click on Student Site.
    Type in your username and password.
    Click on the Login button.
    Click on the plus sign icon for Resources on the left side of the screen.
    Click on the name of the textbook for this course.
    Expand the menu on the left to locate all the chapters.
    Navigate to the desired content (checklists, videos, animations, etc.).

    Note: Clicking on the URLs in the APA citations for the Resources from the textbook will not link directly to the desired online content. Use the online menu to navigate to the desired content.

    Module 1 Assignment: Case Study Analysis

    An understanding of cells and cell behavior is a critically important component of disease diagnosis and treatment. But some diseases can be complex in nature, with a variety of factors and circumstances impacting their emergence and severity.

    Effective disease analysis often requires an understanding that goes beyond isolated cell behavior. Genes, the environments in which cell processes operate, the impact of patient characteristics, and racial and ethnic variables all can have an important impact. NURS 6501 Module 1: Foundational Concepts of Cellular Pathophysiology

    Photo Credit: Getty Images/Hero Images

    An understanding of the signals and symptoms of alterations in cellular processes is a critical step in the diagnosis and treatment of many diseases. For APRNs, this understanding can also help educate patients and guide them through their treatment plans.

    In this Assignment, you examine a case study and analyze the symptoms presented. You identify cell, gene, and/or process elements that may be factors in the diagnosis, and you explain the implications to patient health.

    To prepare:

    By Day 1 of this week, you will be assigned to a specific case study for this Case Study Assignment. Please see the “Course Announcements” section of the classroom for your assignment from your Instructor.

    The Assignment (1- to 2-page case study analysis)

    Develop a 1- to 2-page case study analysis in which you:

    Explain why you think the patient presented the symptoms described.
    Identify the genes that may be associated with the development of the disease.
    Explain the process of immunosuppression and the effect it has on body systems.

    By Day 7 of Week 2

    Submit your Case Study Analysis Assignment by Day 7 of Week 2.

    Reminder: The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. The sample paper provided at the Walden Writing Center provides an example of those required elements (available at https://academicguides.waldenu.edu/writingcenter/templates). All papers submitted must use this formatting.

    Submission and Grading Information

    To submit your completed Assignment for review and grading, do the following:

    Please save your Assignment using the naming convention “M1Assgn+last name+first initial.(extension)” as the name.
    Click the Module 1 Assignment Rubric to review the Grading Criteria for the Assignment.
    Click the Module 1 Assignment link. You will also be able to “View Rubric” for grading criteria from this area.
    Next, from the Attach File area, click on the Browse My Computer button. Find the document you saved as “M1Assgn+last name+first initial.(extension)” and click Open.
    If applicable: From the Plagiarism Tools area, click the checkbox for I agree to submit my paper(s) to the Global Reference Database.
    Click on the Submit button to complete your submission.

    Grading Criteria

    To access your rubric:

    Module 1 Assignment Rubric

    Check Your Assignment Draft for Authenticity

    To check your Assignment draft for authenticity:

    Submit your Module 1 Assignment draft and review the originality report.

    Submit Your Assignment by Day 7 of Week 2

    To participate in this Assignment:

    Module 1 Assignment

     

    What’s Coming Up in Module 2?

    Photo Credit: [BrianAJackson]/[iStock / Getty Images Plus]/Getty Images

    In Module 2, you will analyze processes related to cardiovascular and respiratory disorders. To do this, you will analyze alterations in the cardiovascular and respiratory systems and the resultant disease processes. You will also consider patient characteristics, including racial and ethnic variables, which may impact physiological functioning and altered physiology.

    Week 3 Knowledge Check: Cardiovascular and Respiratory Disorders

    In the Week 3 Knowledge Check, you will demonstrate your understanding of the topics covered during Module 2. This Knowledge Check will be composed of a series of questions related to specific scenarios provided. It is highly recommended that you review the Learning Resources in their entirety prior to taking the Knowledge Check, since the resources cover the topics addressed. Plan your time accordingly.

    How to create Testimonial Carousel using Bootstrap5

    Clients' Reviews about Our Services