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For the final exam, I’ll be asking you to consider how this patient’s uncontrolled type 1 diabetes impacts multiple physiologic functions across organ systems, including: endocrine (blood glucose regulation), renal tubular reabsorption of glucose, and MAP. To prepare for the questions you’ll see from this case, I’d like you to focus on the following areas:
(1) Endocrine system: understand the role of insulin and mechanism by which it regulates blood glucose levels; why does a type 1 diabetic show elevated blood glucose levels?
(2) Renal system – Tubular reabsorption of glucose (and other substances): review how mechanisms for tubular reabsorption of various substances is coupled to reabsorption of Na+; what type of transport is this? why?
(3) Based on your understanding of the renal tubular reabsorption of glucose, why does a type 1 diabetic show glucose in urine?
(4) MAP: The patient in this case study shows polyuria and decreased MAP (hypotension). How does polyuria lead to hypotension in this patient? Focus on the mechanism here – start by identifying which MAP variable is altered by the polyuria and go from there.
(5) MAP: This patient is also experiencing weak and rapid pulse rate (tachycardia – pulse is 120 bpm). Explain why this is occurring by linking this as a reflex compensatory response to the decreased MAP & discuss the mechanism (including effector).
( I will upload case study & textbook )
Textbook:
Chapter 13: Respiratory Physiology (mheducation.com)
Chapter 14: The Kidneys and Regulation of Water and Inorganic Ions (mheducation.com)
Link of text book that helped answer Case Study:
26.4 Acid-Base Balance – Anatomy & Physiology (oregonstate.education)
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