Hallucinogens – Magic Mushroom

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Hallucinogens – Magic Mushroom
            First of all, Magic mushroom (psilocybin) is a psychedelic agent (serotonergic hallucinogens) with psychoactive effects on mood, perception, and cognition (Matzopoulos et al., 2021). Psilocybin-containing mushrooms have been utilized for several millennia for medical and spiritual purposes (Johnson et al., 2018). Compared to tobacco, alcohol, and opioids, psychedelics are characterized by benign toxicity profiles and low addictive potential. Psilocybin use is linked with reduced suicidality and reduced level of psychological stress compared to users of other illicit or recreational drugs (Matzopoulos et al., 2021). In addition, psilocybin use is associated with acute reduction of clinical signs and symptoms of depressive disorders (Rucker et al., 2022). Classical serotonergic-psychedelics are not associated with organ damage, long-term neuropsychological deficits, and neurotoxic effects. There is limited possibility that psilocybin use can cause physical dependence. However, a study on the US population indicated that there is no significant association between the use of psychedelics and increased rate of mental illness, addiction, and recurring, or prolonged, perceptual effects (Matzopoulos et al., 2021). People who use psilocybin are less likely to experience opioid use disorder (Rodriguez, 2022).  Psilocybin is not associated with physical dependence potential and is effective in management of cancer-associated substance use disorders and psychiatric distress. It has a good safety profile (Johnson et al., 2018). With this in consideration, I agree that there no justifiable reason to classify Magic mushroom as a controlled substance since evidence indicates that it does not result in physical dependence.
 

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